Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate

(2020) Cerium-doped flower-shaped ZnO nano-crystallites as a sensing component for simultaneous electrochemical determination of epirubicin and methotrexate. Microchimica Acta. p. 11. ISSN 0026-3672

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Abstract

A glassy carbon electrode (GCE) was modified with cerium-doped ZnO nanoflowers (Ce-ZnO/GCE) to obtain a sensor for direct simultaneous detection of the cancer drugs epirubicin and methotrexate. XRD, SEM and EDX techniques were used to characterize their morphology and structure. Electrochemical impedance spectroscopy was applied to characterize the electrochemical features of the modified GCE. The experimental conditions were optimized. Diffusion coefficients and heterogeneous rate constants were determined for the oxidation of epirubicin. The differential pulse voltammetric response to epirubicin has a peak near 0.7 V (vs. Ag/AgCl at a scan rate of 50 mV s(-1)) and is linear in the 0.01 to 600 mu M concentration range, and the detection limit is 2.3 nM (S/N = 5). The differential pulse voltammetric response to methotrexate has a peak near 0.75 V (vs. Ag/AgCl and the same scan rate) and is linear in the 0.01 to 500 mu M concentration range, and the detection limit is 6.3 nM (S/N = 5). The method was applied to the simultaneous determination of epirubicin and methotrexate in pharmaceutical injections and in spiked diluted blood specimens.

Item Type: Article
Keywords: Cerium-doped flower-shaped ZnO nano-crystallites Epirubicin Methotrexate Modified electrode Voltammetry screen-printed electrode glassy-carbon electrode morphology sensor vinblastine cisplatin cancer blood Chemistry
Divisions:
Page Range: p. 11
Journal or Publication Title: Microchimica Acta
Journal Index: ISI
Volume: 187
Number: 1
Identification Number: https://doi.org/10.1007/s00604-019-4016-2
ISSN: 0026-3672
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mubam.ac.ir/id/eprint/858

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