Abstract

In the present work, a rapid and sensitive method for electrochemical determination of acetaminophen (AC) based on the modified screen printed carbon electrode (MSPCE) developed. Cyclic voltammetry was used to study the electrochemical behavior of AC and its determination was conducted by applying square wave voltammetry (SWV). The MSPCE in comparison with bare SPCE exhibited enhanced electrocatalytic activity toward the oxidation of AC. A single irreversible oxidation peak was observed at potentials of 590 mV and 480 mV on the MSPCE and bare SPCE, respectively. Based on the results, the linear oxidation peak current was 0.5-220 mu M and the correlation coefficient was obtained to be 0.9973. According to the three times standard deviation (3S(b)) of the blank, the limit of detection was calculated 0.1 mu M. The MSPCE was used for quantitative analysis of acetaminophen in AC ampule and AC tablet samples and the results indicate the feasibility of the amperometric method for AC analysis in routine detection.