Abstract

Objective: The aim of this study is to evaluate the hepatoprotective effect of methanolic and aqueous extract of Capparis spinosa L. fruit in mice. Methods: The hepatoprotective effects of methanolic extract of C. spinosa was assessed by measuring the serum levels of enzymes including bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the treated mice after oral administration of C. spinosa at the doses of 250, 500, and 750 mu g/kg, respectively, for 14 days. Results: The results demonstrated that C. spinosa at the tested doses of 250, 500, and 750 mg/kg had no significant toxicity on the serum liver enzymes of ALT, AST, ALP, and bilirubin. Conclusion: The findings revealed the hepatoprotective effects of methanolic extract of C. spinosa in mice.