(UNSPECIFIED) Association of eNOS and ACE Polymorphisms with Retinopathy of Prematurity: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology. p. 12. ISSN 1551-3815
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Abstract
Background: We performed a meta-analysis to clarify the association of endothelial nitric oxide synthase (eNOS) and angiotensin I-converting enzyme (ACE) gene polymorphisms with retinopathy of prematurity (ROP) risk. Methods: PubMed, Medline, and Embase literatures up to June 01, 2019, were reviewed. Odds ratios (ORs) and 95 confidence intervals (CIs) were used to estimate the strength of associations. Results: Eighteen case-control studies including 14 studies (810 cases and 1754 controls) on eNOS polymorphisms and four studies (1014 cases and 1215 controls) on ACE I/D polymorphism were selected. Overall, analysis showed that infants with the ACE I/D polymorphism have an increased susceptibility to ROP. No association of eNOS 27-bp, 894 G > T and -786 T > C polymorphisms with ROP risk was found. Conclusion: ACE I/D polymorphism may serve as genetic biomarker of increased ROP risk. The eNOS polymorphisms do not appear to influence susceptibility to ROP.
| Item Type: | Article |
|---|---|
| Keywords: | Retinopathy of Prematurity endothelial nitric oxide synthase angiotensin I-converting enzyme polymorphism meta-analysis insertion/deletion polymorphism gene polymorphisms update risk t-786c Pathology Pediatrics |
| Divisions: | |
| Page Range: | p. 12 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Journal Index: | ISI |
| Identification Number: | https://doi.org/10.1080/15513815.2019.1652378 |
| ISSN: | 1551-3815 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/420 |
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