(UNSPECIFIED) Association of Promoter Region Polymorphisms of IL-6 and IL-18 Genes with Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology. p. 14. ISSN 1551-3815
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Abstract
Background: The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. Methods: An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. Results: A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms in overall population. Further, subgroup analyses by ethnicity revealed that the IL-6 -174 G > C and -634 G > C polymorphisms were significantly associated with risk of RPL risk in Asians. Conclusions: Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL.
| Item Type: | Article |
|---|---|
| Keywords: | recurrent miscarriage abortion interleukin polymorphism association interleukin-18 gene spontaneous-abortion susceptibility cancer women Pathology Pediatrics |
| Divisions: | |
| Page Range: | p. 14 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Journal Index: | ISI |
| Identification Number: | https://doi.org/10.1080/15513815.2019.1652379 |
| ISSN: | 1551-3815 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/419 |
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