Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

Simultaneous determination of amitriptyline and venlafaxine using a novel voltammetric sensor of carbon paste electrode modified with octahedral Pd2+-doped Co3O4 composite

(2023) Simultaneous determination of amitriptyline and venlafaxine using a novel voltammetric sensor of carbon paste electrode modified with octahedral Pd2+-doped Co3O4 composite. Materials Chemistry and Physics. p. 11. ISSN 0254-0584

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Abstract

We modified the surface of carbon paste electrode (CPE) with octahedral palladium (Pd2+)-doped cobaltite (Co3O4) composite (Oh-Pd2+:Co3O4-C/CPE) as a novel voltammetric sensor to simultaneously detect amitriptyline and venlafaxine. The techniques of differential pulse voltammetry, electrochemical impedance spectroscopy, chronoamperometry and cyclic voltammetry were employed to determine the electrochemical responses of these analytes. The findings highlighted the ability of as-fabricated sensor to facilitate the amitriptyline and venlafaxine oxidation. Peak currents for both analytes differed linearly with their concentrations (between 1.0 x 10-8 M to 9.0 x 10-4 M) for the analytical performance of the sensor. The limit of detection calculated by differential pulse voltammetry was 2.31 nM for amitriptyline and 3.56 nM for venlafaxine. We found several advantages for the modified electrode, including a simple preparation method, impressive sensitivity, admirable repeatability, and narrow detection limitations. The proposed sensor was able to detect amitriptyline and venlafaxine in real drug, serum and urine specimens.

Item Type: Article
Keywords: Amitriptyline Venlafaxine Palladium Cobaltite composite Modified electrode zirconia ceramics chip thickness performance antidepressant lubrication Materials Science
Divisions:
Page Range: p. 11
Journal or Publication Title: Materials Chemistry and Physics
Journal Index: ISI
Volume: 296
Identification Number: https://doi.org/10.1016/j.matchemphys.2022.127176
ISSN: 0254-0584
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mubam.ac.ir/id/eprint/1488

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