(2020) Association of REarranged during Transfection (RET) c.73+9277T > C and c.1356 > a Polyrnorphisrns with Susceptibility to Hirschsprung Disease: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology. pp. 476-490. ISSN 1551-3815
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Abstract
Background: Previous studies have suggested a close association between REarranged during Transfection (RET) c.73 + 9277T > C and c.135G> A polymorphisms and Hirschsprung disease (HSCR) susceptibility. The results are inconsistent and contradictory. Thus, we performed a meta-analysis to evaluate the association of RET c.73 + 9277T> C and c.135G > A polymorphisms with risk of HSCR. Methods: The eligible literatures were searched by PubMed, Google Scholar, EMBASE, and CNKI up to August 5 2019. Results: A total of 20 studies including 10 studies with 1136 cases and 2420 controls on c.73 + 9277T> C and 10 studies with 917 cases and 1159 controls on c.135G > A were selected. Pooled ORs revealed that c.73 + 9277T > C and c.135G > A polymorphisms were significantly associated with an increased risk of HSCR. Moreover, stratified analysis revealed that c.73 + 9277T> C and c.135G > A polymorphisms were associated with HSCR risk in Asian, Caucasian and Chinese populations. Conclusions: This meta-analysis result indicated that the RET c.73 + 9277T> C and c.135G > A polymorphisms were associated with susceptibility to HSCR.
| Item Type: | Article |
|---|---|
| Keywords: | Hirschsprung disease birth defect RET gene polymorphism meta-analysis Pathology Pediatrics |
| Divisions: | |
| Page Range: | pp. 476-490 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Journal Index: | ISI |
| Volume: | 39 |
| Number: | 6 |
| Identification Number: | https://doi.org/10.1080/15513815.2019.1672225 |
| ISSN: | 1551-3815 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/1080 |
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