(2021) Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy. IUBMB life. pp. 659-669. ISSN 1521-6543
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Abstract
One of the most common malignant tumors is hepatocellular carcinoma (HCC). Progression of HCC mainly results from highly complex molecular and pathological pathways. Midkine (MDK) is a growth factor that impacts viability, migration, and other cell activities. Since MDK has been involved in the inflammatory responses, it has been claimed that MDK has a crucial role in HCC. MDK acts as an anti-apoptotic factor, which mediates tumor cell viability. In addition, MDK blocks anoikis to promote metastasis. There is also evidence that MDK is involved in angiogenesis. It has been shown that the application of anti-MDK approaches might be promising in the treatment of HCC. Besides, due to the elevated expression in HCC, MDK has been proposed as a biomarker in the prognosis and diagnosis of HCC. In this review, we will discuss the role of MDK in HCC. It is hoped that the development of new strategies concerning MDK-based therapies will be promising in HCC management.
| Item Type: | Article |
|---|---|
| Keywords: | biomarker cancer gene therapy hepatocellular carcinoma Midkine Abbreviations AFP Alpha‐ feto preotein ALK Anaplastic lymphoma kinase DRDeath receptor ECMExtracellular matrix EMT Epithelial‐ mesenchymal transition ERKExtracellular‐ signal‐ regulated kinase HCCHepatocellular Carcinoma IGF‐ 1RInsulin‐ like growth factor‐ 1 receptor IRS‐ 1Insulin receptor substrate‐ 1 JAKJanus kinase JNK c‐ Jun N‐ terminal kinases LTBP3 Latent Transforming Growth Factor Beta Binding Protein 3 LRP‐ 1Low‐ density lipoprotein receptor‐ related protein MAPK Mitogen‐ activated protein kinase MDKMidkine NEGFNeurite growth‐ promoting factor NF‐ κ B Nuclear factor κ B PI3K Phosphoinositide 3‐ kinase PGRN Progranulin PLSCR1 Phospholipid Scramblase 1 PTNPleiotrophin PTPζ Protein tyrosine phosphatase‐ ζ STAT Signal transducer and activator of transcription TGF‐ β Transforming growth factor‐ β TRAIL TNF‐ related apoptosis‐ inducing ligand VLA4Very late antigen‐ 4 ZFAS1 ZNFX1 antisense RNA 1 Biochemistry & Molecular Biology Cell Biology |
| Divisions: | |
| Page Range: | pp. 659-669 |
| Journal or Publication Title: | IUBMB life |
| Journal Index: | ISI |
| Volume: | 73 |
| Number: | 4 |
| Identification Number: | https://doi.org/10.1002/iub.2458 |
| ISSN: | 1521-6543 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/1024 |
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