Abstract

In the present work, a simple and low-cost protocol for determination of gliclazide using modified screen-printed electrodes (SPE) was reported. The immobilization of magnetic core-shell manganese ferrite nanoparticles (MCSNP) onto SPE provides a unique opportunity for charge transfer process. Consequently, the electroanalytical sensing of gliclazide was explored at the modified SPE surface. The response of the modified electrode was linear, in the concentration range from 0.5 to 300.0 mu M, and a detection limit of 100 nM was obtained. The proposed method was successfully employed for gliclazide determination in pharmaceutical and human urine samples. The method showed tremendous reproducibility and intra- and inter-day stability, and has proved to be highly reliable for gliclazide analysis in clinical samples.