(2019) Asociace polymorfizmů mthfr 677c>t, 1298a>c a mtr 2756a>g s rizikem rozvoje retinoblastomu. Klinicka Onkologie. pp. 375-379. ISSN 0862495X (ISSN)
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Abstract
Background: The MTHFR 677C>T, 1298A>C and MTR 2756A>G polymorphisms have been investigated in several different cancer types. However, the role of these polymorphisms in the development of retinoblastoma remains unclear. Here, we have evaluated the association of the MTHFR 677C>T, 1298A>C and MTR 2756A>G polymorphisms with the risk of retinoblastoma in Iranian children. Methods: The MTHFR 677C>T, 1298A>C and MTR 2756A>G polymorphisms in 66 patients with retinoblastoma and 99 age-and gender-matched healthy controls were detected on the ABI PRISMs 7500 Real-Time PCR System. The association between these polymorphisms and the risk of retinoblastoma was analysed by an odds ratio with a 95 confidence interval. Results: Our results showed a significant association between the MTR 2756A>G polymorphism and the risk of retinoblastoma. In the MTR 2756A>G polymorphism, the AG (39.4) and GG (9.1) genotype frequencies in the cases were found to be higher in comparison with the controls, showing a significant difference (p < 0.05). However, no significant difference was observed in the allelic or genotypic frequencies for both the MTHFR 677C>T and 1298A>C polymorphisms in the retinoblastoma patients of the controls (p > 0.05). Conclusions: Our results suggested that the MTR 2756A>G polymorphism might be associated with an increased risk of retinoblastoma in Iranian children. However, the results show that the MTHFR 677C>T and 1298A>C polymorphisms are not significantly associated with an increased risk of retinoblastoma. © 2019, Czech Medical Association J.E. Purkyne. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Childhood MTHFR gene MTR gene Retinoblastoma Single-nucleotide polymorphism mthfr protein mtr protein tumor protein unclassified drug methylenetetrahydrofolate reductase (NADPH2) MTHFR protein, human Article cancer genetics cancer risk case control study child childhood cancer controlled study female gene frequency genetic association human infant Iranian people major clinical study male real time polymerase chain reaction single nucleotide polymorphism epidemiology genetic predisposition genetics genotype Iran newborn preschool child retina tumor risk factor Case-Control Studies Child, Preschool Genetic Predisposition to Disease Humans Infant, Newborn Polymorphism, Single Nucleotide Retinal Neoplasms Risk Factors |
| Divisions: | |
| Page Range: | pp. 375-379 |
| Journal or Publication Title: | Klinicka Onkologie |
| Journal Index: | Scopus |
| Volume: | 32 |
| Number: | 5 |
| Identification Number: | https://doi.org/10.14735/amko2019375 |
| ISSN: | 0862495X (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/943 |
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