(2020) Avocado–Soybean unsaponifiables: A panoply of potentialities to be exploited. Biomolecules. ISSN 2218273X (ISSN)
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Abstract
Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado–soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
| Item Type: | Article |
|---|---|
| Keywords: | Avocado–soybean unsaponifiables Carothenes Menopause Osteoarthritis Phytosterols Scleroderma Tocopherol alpha tocotrienol carotene chlorophyll cyclooxygenase 2 estrogen receptor beta fibronectin immunoglobulin enhancer binding protein inducible nitric oxide synthase interleukin 1beta interleukin 4 interleukin 6 interleukin 8 macrophage inflammatory protein 1 matrix metalloproteinase osteocalcin phytosterol piascledine sitosterol soybean oil tissue inhibitor of metalloproteinase 1 transforming growth factor beta3 antiinflammatory activity antioxidant activity autoimmune disease avocado diffuse scleroderma drug efficacy drug isolation drug mechanism drug purification drug safety gas liquid chromatography high performance liquid chromatography high performance thin layer chromatography human mass spectrometry menopausal syndrome nonhuman nuclear magnetic resonance postmenopause quality of life Review saponification soybean |
| Divisions: | |
| Journal or Publication Title: | Biomolecules |
| Journal Index: | Scopus |
| Volume: | 10 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.3390/biom10010130 |
| ISSN: | 2218273X (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/932 |
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