(2020) Synthesis of bifunctional cabbage flower–like Ho3+/NiO nanostructures as a modifier for simultaneous determination of methotrexate and carbamazepine. Analytical and Bioanalytical Chemistry. pp. 1011-1024. ISSN 16182642 (ISSN)
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Abstract
Cabbage flower–like Ho3+/NiO nanostructure (CFL-Ho3+/NiO NSs) with significant electrocatalytic oxidation has been published for the first time. First, structure and morphology of CFL-Ho3+/NiO-NSs have been described by XRD, SEM, and EDX methods. Then, CFL-Ho3+/NiO-NSs have been applied as a modifier for simultaneous electrochemical detection of methotrexate (MTX) and carbamazepine (CBZ). Functions of the modified electrode have been dealt with through electrochemical impedance spectroscopy (EIS). It has been demonstrated that the electrode response has been linear from 0.001–310.0 μM with a limit of detection of 5.2 nM and 4.5 nM (3 s/m) through DPV for MTX and CBZ. Diffusion coefficient (D) and heterogeneous rate constant (kh) have been detected for MTX and CBZ oxidation at the surface of the modified electrode. Moreover, CFL-Ho3+/NiO-NS/GCE has been employed for determining MTX and CBZ in urine and drug specimens. Outputs showed the analyte acceptable recovery. Therefore, the electrode could be applied to analyze both analytes in drug prescription and clinical laboratories. Figure not available: see fulltext.. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
| Item Type: | Article |
|---|---|
| Keywords: | Cabbage flower–like Ho3+/NiO nanostructure Carbamazepine Methotrexate Voltammetry Amides Chemical detection Electrocatalysis Electrochemical impedance spectroscopy Morphology Nanostructures Rate constants Electro-catalytic oxidation ELectrochemical detection Heterogeneous rate constant Modified electrodes Simultaneous determinations Structure and morphology Electrochemical electrodes analgesic agent holmium immunosuppressive agent nanomaterial nickel nickel monoxide blood chemistry drug monitoring electrochemical analysis human limit of detection oxidation reduction reaction procedures tablet urine Analgesics, Non-Narcotic Electrochemical Techniques Humans Immunosuppressive Agents Oxidation-Reduction Tablets |
| Divisions: | |
| Page Range: | pp. 1011-1024 |
| Journal or Publication Title: | Analytical and Bioanalytical Chemistry |
| Journal Index: | Scopus |
| Volume: | 412 |
| Number: | 4 |
| Identification Number: | https://doi.org/10.1007/s00216-019-02326-8 |
| ISSN: | 16182642 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/926 |
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