Abstract

Nanoparticles are known to have a distinctive interaction at the molecular level with biological systems and widely used in cancer treatment. Silver nanoparticles (AgNPs) was characterized by UV-visible, XRD and TEM. The phytochemical screening was performed to study the plant chemical compounds. The cytotoxic properties of AgNPs on breast cancer cells (MCF-7 line) have obtained using MTT assay. The potent inhibitory effects of nanoparticles on Cyclin-D1 gene expression were demonstrated by western blotting. The AgNPs (7-10 nm) were synthesized using Tamarix hispida. The phytochemical analysis showed that T. hispida is rich in proteins, carbohydrates, and alkaloids. The western blot analysis showed that the AgNPs inhibits the Cyclin D1 expression and decreases cell proliferation. In conclusion, the results provide a promising approach for designing a new AgNPs-mediated drug delivery study due to the remarkable exhibition of cytotoxicity activity for cancer therapy.