Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury

(2018) Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury. Brain research bulletin. pp. 169-175. ISSN 1873-2747 (Electronic) 0361-9230 (Linking)

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Brain edema and increased intracranial pressure (ICP) are among the main causes of neurological disturbance and mortality following traumatic brain injury (TBI). Since pregabalin neuroprotective effects have been shown, this study was performed to evaluate the possible neuroprotective effects of pregabalin in experimental TBI of male rats. Adult male Wistar rats were divided into 4 groups: sham, vehicle, pregabalin 30mg/kg and pregabalin 60mg/kg. TBI was induced in vehicle and pregabalin groups by Marmarou method. Pregabalin was administered 30min after TBI. Sham and vehicle groups received saline. Brain water and Evans blue content and histopathological changes were evaluated 24, 5 and 24h after TBI, respectively. The ICP and neurological outcomes (veterinary coma scale, VCS) were recorded before, 1h and 24h post TBI. The results showed a significant reduction in brain water content and ICP, and a significant increase in VCS of pregabalin group (60mg/kg) as compared to vehicle group (P<0.05). Also, pregabalin reduced brain edema and apoptosis score as compared to vehicle group. Post TBI pregabalin administration revealed a delayed but significant improvement in ICP and neurological outcomes in experimental TBI. The underlying mechanism(s) was not determined and needs further investigation.

Item Type: Article
Keywords: Animals Apoptosis/drug effects Brain/*drug effects/metabolism/pathology Brain Edema/*drug therapy/etiology/metabolism/pathology Brain Injuries, Traumatic/complications/*drug therapy/metabolism/pathology Capillary Permeability/drug effects Disease Models, Animal Dose-Response Relationship, Drug Intracranial Pressure/drug effects Male Neuroprotective Agents/*pharmacology Pregabalin/*pharmacology Rats, Wistar *Brain edema *Intracranial pressure *Neurological outcome *Pregabalin *Traumatic brain injury
Page Range: pp. 169-175
Journal or Publication Title: Brain research bulletin
Journal Index: Pubmed
Volume: 140
Identification Number:
ISSN: 1873-2747 (Electronic) 0361-9230 (Linking)
Depositing User: مهندس مهدی شریفی

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