Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

G allele at-924 A > G position of FoxP3 gene promoter as a risk factor for tuberculosis

(2017) G allele at-924 A > G position of FoxP3 gene promoter as a risk factor for tuberculosis. Bmc Infectious Diseases. p. 6. ISSN 1471-2334

Full text not available from this repository.

Official URL:


Background: Forkhead box protein 3 (FoxP3) is an important factor for development and function of Regulatory T cells (Treg). Studies have found an association between common gene polymorphisms in FoxP3 and some infectious diseases. The aim of this study was to evaluate possible associations between two Single nucleotide polymorphisms (SNPs) in the promoter of the FoxP3 gene to susceptibility to tuberculosis (TB) and the alteration of Foxp3 gene expression. Methods: The pattern distribution of genotype at two position, -3279 A > C (rs3761548) and -924 A > G (rs2232365) on the promoter of FoxP3 gene was evaluated using polymerase chain reaction-single specific primer (PCR-SSP) method in 183 tuberculosis patients and 183 healthy control. In addition the quantity of FoxP3 gene expression at mRNA level was identified by the real-time PCR. Results: The frequency of G allele at -924 A > G was significantly higher was higher in TB patients (59.5) than control group (39.5) (P <= 0.05). In addition, our data viewed approximately 5-folds more FoxP3 gene expression in female patients with GG genotype in comparison to female healthy cases with the same genotype (P <= 0.001). There was no statistically significant differences between the distribution pattern of -3279 A > C polymorphism in patients and healthy individuals along with it effect on the FoxP3 gene expression among both groups (P > 0.05). Conclusions: Our outcome suggests that the -924 A > G polymorphism leads to enhance FoxP3 gene expression and susceptibility to tuberculosis in the sex dependent manner. This event may rise the count of Treg cells and modulate the immune response against tuberculosis.

Item Type: Article
Keywords: Forkhead box protein 3 Gene polymorphisms Regulatory T cells Tuberculosis regulatory t-cells mycobacterium-tuberculosis active tuberculosis susceptibility polymorphism expression infection mutations Infectious Diseases
Page Range: p. 6
Journal or Publication Title: Bmc Infectious Diseases
Journal Index: ISI
Volume: 17
Identification Number:
ISSN: 1471-2334
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item