(2017) LEISHMANICIDAL EFFECTS OF OLEA EUROPAEA LINN. EXTRACT AGAINST PROMASTIGOTE AND AMASTIGOTE FORMS OF SOME LEISHMANIA SPP. International Journal of Pharmaceutical Sciences and Research. pp. 4869-4874. ISSN 0975-8232
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Abstract
Here, we evaluated the in vitro antileishmanial activities of Olea europaea linn. leave extract (OLE) on some Leishmania spp. OLE (0-160.. g/mL) was considered against promastigote and intracellular amastigote forms of L. tropica (MHOM/IR/2002/Mash2) and L. major (MRHO/IR/75/ER) using MTT assay and in a macrophage model, respectively. The obtained findings demonstrated that OLE significantly (P<0.05) inhibited the growth rate of promastigote and amastigotes as a dose and time dependent response. To conclude, the current investigation exhibited effective antileishmanial activity of OLE.
| Item Type: | Article |
|---|---|
| Keywords: | Olive Leishmania Mice Macrophage in-vitro antileishmanial polyphenols cutaneous leishmaniasis olive oleuropein assay identification antioxidant products Pharmacology & Pharmacy |
| Divisions: | |
| Page Range: | pp. 4869-4874 |
| Journal or Publication Title: | International Journal of Pharmaceutical Sciences and Research |
| Journal Index: | ISI |
| Volume: | 8 |
| Number: | 11 |
| Identification Number: | https://doi.org/10.13040/ijpsr.0975-8232.8(11).4869-74 |
| ISSN: | 0975-8232 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/604 |
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