Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles

(2017) Leishmanicidal Activity of Biogenic Fe3O4 Nanoparticles. Scientia Pharmaceutica. p. 9. ISSN 0036-8709

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Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe3O4 (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanicidal efficiency of green synthesized IONPs. This is the first report of the leishmanicidal efficiency of green synthesized IONPs against Leishmania major. The resulting biosynthesized IONPs were characterized by ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The leishmanicidal activity of IONPS was studied via 3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results showed the fabrication of the spherical shape of monodisperse IONPs with a size 4 +/- 2 nm. The UV-visible spectrophotometer absorption peak was at 334 nm. The leishmanicidal activity of biogenic iron oxide nanoparticles against Leishmania major (promastigote) was also studied. The IC50 of IONPs was 350 mu g/mL. In this report, IONPs were synthesized via a green method. IONPs are mainly spherical and homogeneous, with an average size of about 4 nm, and were synthesized here using an eco-friendly, simple, and inexpensive method.

Item Type: Article
Keywords: biosynthesis iron oxide nanoparticles IONPs leishmanicidal iron-oxide nanoparticles silver nanoparticles green synthesis antimicrobial activities rosmarinus-officinalis escherichia-coli biosynthesis antibacterial antioxidant extract Pharmacology & Pharmacy
Page Range: p. 9
Journal or Publication Title: Scientia Pharmaceutica
Journal Index: ISI
Volume: 85
Number: 4
Identification Number:
ISSN: 0036-8709
Depositing User: مهندس مهدی شریفی

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