(2023) Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macro-phage Polarization in Inflammatory Diseases. Current molecular pharmacology. pp. 2-14. ISSN 18744672 (ISSN)
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Abstract
Background: Due to their plasticity, macrophages exert critical effects on both promoting and suppressing inflammatory processes. Pathologic inflammatory conditions are frequently correlated with dynamic alterations in macrophage activation, with classically activated M1 cells associated with the pro-motion and maintenance of inflammation and M2 cells being linked to the resolution or smouldering of chronic inflammation. Inflammation deputes a common feature of various chronic diseases and the direct involvement in the insurgence and development of these conditions. Macrophages participate in an auto-regulatory loop characterizing the inflammatory process, as they produce a wide range of biologically active mediators that exert either deleterious or beneficial effects during the inflammation. Therefore, balancing the favorable ratios of M1/M2 macrophages can help ameliorate the inflammatory landscape of pathologic conditions. Curcumin is a component of turmeric with many pharmacological properties. Objective: Recent results from both in-vivo and in-vitro studies have indicated that curcumin can affect polarization and/or functions of macrophage subsets in the context of inflammation-related diseases. There is no comprehensive review of the impact of curcumin on cytokines involved in macrophage polarization in the context of inflammatory diseases. The present review will cover some efforts to explore the underlying molecular mechanisms by which curcumin modulates the macrophage polarization in dis-tant pathological inflammatory conditions, such as cancer, autoimmunity, renal inflammation, stroke, ath-erosclerosis, and macrophage-driven pathogenesis. Results: The accumulation of the findings from in vitro and in vivo experimental studies suggests that curcumin beneficially influences M1 and M2 macrophages in a variety of inflammatory diseases with unfavorable macrophage activation. Conclusion: Curcumin not only enhances anti-tumor immunity (via shifting M polarization towards M1 phenotype and/or up-regulation of M1 markers expression) but ameliorates inflammatory diseases, including autoimmune diseases (experimental autoimmune myocarditis and Behcet's disease), nephropathy, chronic serum sickness, stroke, and atherosclerosis. © 2023 Bentham Science Publishers.
| Item Type: | Article |
|---|---|
| Keywords: | Atherosclerosis autoimmunity Cancer Curcumin Immunomodulation Inflammation Macrophages Stroke angiotensin 1 receptor arginase 1 CXCL1 chemokine CXCL2 chemokine CXCL3 chemokine CXCL9 chemokine epithelial derived neutrophil activating factor 78 gamma interferon gamma interferon inducible protein 10 granulocyte macrophage colony stimulating factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha immunoglobulin enhancer binding protein inducible nitric oxide synthase intercellular adhesion molecule 1 interferon regulatory factor 5 interleukin 1 interleukin 10 interleukin 12 interleukin 13 interleukin 17 interleukin 18 interleukin 21 interleukin 23 interleukin 4 interleukin 6 interleukin 8 Janus kinase lipopolysaccharide monocyte chemotactic protein 1 peroxisome proliferator activated receptor gamma reactive oxygen metabolite STAT1 protein STAT3 protein STAT4 protein synaptotagmin I toll like receptor transcription factor AP 1 transforming growth factor beta tumor necrosis factor antiinflammatory activity antineoplastic activity antioxidant activity Behcet disease CD4+ T lymphocyte cell differentiation cell infiltration cell membrane depolarization cell proliferation cerebrovascular accident cytokine production cytokine release down regulation enzyme phosphorylation experimental autoimmune myocarditis glioblastoma glomerulonephritis human inflammatory bowel disease inflammatory disease insulin dependent diabetes mellitus kidney disease M1 macrophage M2 macrophage macrophage activation multiple sclerosis nonhuman protein expression protein phosphorylation regulatory T lymphocyte Review rheumatoid arthritis serum sickness Sjoegren syndrome systemic lupus erythematosus Th1 cell upregulation macrophage Humans |
| Divisions: | |
| Page Range: | pp. 2-14 |
| Journal or Publication Title: | Current molecular pharmacology |
| Journal Index: | Scopus |
| Volume: | 16 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.2174/1874467215666220324114624 |
| ISSN: | 18744672 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/1540 |
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