Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite

(2022) Simultaneous Electrochemical Determination of Chlorzoxazone and Diclofenac on an Efficient Modified Glassy Carbon Electrode by Lanthanum Oxide@ Copper(I) Sulfide Composite. Frontiers in Chemistry. p. 889590. ISSN 2296-2646 (Print) 2296-2646 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/35783211

Abstract

This study synthesized a La2O3@snowflake-like Cu2S composite to fabricate an electrochemical sensor for sensitively simultaneous detection of diclofenac and chlorzoxazone exploiting an easy hydrothermal approach, followed by analysis with XRD, FE-SEM, and EDX methods. According to voltammetric studies, the electrocatalytic diclofenac and chlorzoxazone oxidations on the electrode modified with La2O3@SF-L Cu2S composites were increased, with greater oxidation currents, as well as the oxidation potential was significantly decreased due to synergetic impact of La2O3@SF-L Cu2S composites when compared with the pure SF-L Cu2S NS-modified electrode. The differential pulse voltammetry findings showed wide straight lines (0.01-900.0 muM) for La2O3 NP@SF-L Cu2S NS-modified electrode with a limit of detection (LOD) of 1.7 and 2.3 nM for the detection of diclofenac and chlorzoxazone, respectively. In addition, the limit of quantification was calculated to be 5.7 and 7.6 nM for diclofenac and chlorzoxazone, respectively. The diffusion coefficient was calculated to be 1.16 x 10(-5)and 8.4 x 10(-6) cm(2)/s for diclofenac and chlorzoxazone oxidation on the modified electrode, respectively. Our proposed electrode was examined for applicability by detecting diclofenac and chlorzoxazone in real specimens.

Item Type: Article
Keywords: chlorzoxazone diclofenac modified electrode nanocomposite voltammetry commercial or financial relationships that could be construed as a potential conflict of interest.
Divisions:
Page Range: p. 889590
Journal or Publication Title: Frontiers in Chemistry
Journal Index: Pubmed
Volume: 10
Identification Number: https://doi.org/10.3389/fchem.2022.889590
ISSN: 2296-2646 (Print) 2296-2646 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.mubam.ac.ir/id/eprint/1433

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