(UNSPECIFIED) The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia. IUBMB life. p. 22. ISSN 1521-6543
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Abstract
The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in different ways like mediating therapeutic resistance; therefore, studying these gene/pathways is essential. This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment.
| Item Type: | Article |
|---|---|
| Keywords: | leukemia NOTCH1 targeted therapy therapeutic resistance chronic lymphocytic-leukemia acute lymphoblastic-leukemia acute myeloid-leukemia secretase inhibitor pf-03084014 splicing factor sf3b1 kappa-b activity gamma-secretase t-all recurrent mutations c-myc Biochemistry & Molecular Biology Cell Biology |
| Divisions: | |
| Page Range: | p. 22 |
| Journal or Publication Title: | IUBMB life |
| Journal Index: | ISI |
| Identification Number: | https://doi.org/10.1002/iub.2660 |
| ISSN: | 1521-6543 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.mubam.ac.ir/id/eprint/1393 |
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