Repository of Research and Investigative Information

Repository of Research and Investigative Information

Bam University of Medical Sciences

The Hepatoprotective mechanisms of 17β-estradiol after traumatic brain injury in male rats: Classical and non-classical estrogen receptors

(2021) The Hepatoprotective mechanisms of 17β-estradiol after traumatic brain injury in male rats: Classical and non-classical estrogen receptors. Ecotoxicology and Environmental Safety. ISSN 01476513 (ISSN)

Full text not available from this repository.

Official URL:


Protective effects of estrogen (E2) on traumatic brain injury (TBI) have been determined. In this study, the hepatoprotective effects of E2 after TBI through its receptors and oxidative stress regulation have been evaluated. Diffuse TBI induced by the Marmarou method in male rats. G15, PHTPP, MPP, and ICI182–780 as selective antagonists of E2 were injected before TBI. The results indicated that TBI induces a significant increase in liver enzymes Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Glutamyl transferase (GGT), and oxidants levels Malondialdehyde (MDA), Nitric oxide (NO) and decreases in antioxidant biomarkers Glutathione peroxidase (GPx) and Superoxide dismutase (SOD) in the brain and liver, and plasma. We also found that E2 significantly preserved levels of these biomarkers and enzymatic activity. All antagonists inhibited the effects of E2 on increasing SOD and GPx. Also, the effects of E2 on brain MDA levels were inhibited by all antagonists, but in the liver, only ICI + G15 + E2 + TBI group was affected. The impacts of E2 on brain and liver and plasma NO levels were inhibited by all antagonists. The current findings demonstrated that E2 probably improved liver injury after TBI by modulating oxidative stress. Also, both classic (ERβ, ERα) and non-classic G protein-coupled estrogen receptor (GPER) receptors are affected in the protective effects of E2. © 2021 The Authors

Item Type: Article
Keywords: 17β-estradiol Estrogen receptors Hepatoprotection Oxidative stress Traumatic brain injury 1,3 bis(4 hydroxyphenyl) 4 methyl 5 4 (2 piperidinylethoxy)phenol 1 h pyrazole 4 (6 bromo 1,3 benzodioxol 5 yl) 3a,4,5,9b 3 h cyclopentacquinolone 4 2 phenyl 5,7 bis(trifluoromethyl) pyrazolo1,5 a]pyrimidin 3 yl]phenol 7alpha,17beta 9 (4,4,5,5,5 pentafluoropentyl)sulfinyl]nonyl] estra 1,3,5(10) triene 3,17 diol alanine aminotransferase alkaline phosphatase aspartate aminotransferase estradiol estrogen receptor estrogen receptor alpha estrogen receptor antagonist estrogen receptor beta G protein coupled estrogen receptor gamma glutamyltransferase glutathione peroxidase malonaldehyde nitric oxide superoxide dismutase unclassified drug antioxidant estrogen protective agent biomarker brain enzyme activity estrogenic compound injury rodent adult animal experiment animal model animal tissue Article blood level brain level controlled study drug mechanism liver injury liver level liver protection male nonhuman rat animal drug effect liver metabolism Alanine Transaminase Animals Antioxidants Aspartate Aminotransferases Brain Injuries, Traumatic Estrogens Malondialdehyde Protective Agents Rats Receptors, Estrogen
Journal or Publication Title: Ecotoxicology and Environmental Safety
Journal Index: Scopus
Volume: 213
Identification Number:
ISSN: 01476513 (ISSN)
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item